The effects of Lactobacillus Reuteri DSM 1738 in infants with colic: an integrative review

Autores/as

DOI:

https://doi.org/10.21680/2446-7286.2025v11n3ID41276

Resumen

Introducción: El cólico infantil (CI) es una enfermedad prevalente en las lactantes, lo que ocurre entre el 10% y el 30% de los bebés de todo el mundo y se caracteriza por llanto, rubor facial, elevación de las extremidades inferiores y flatulencia. Lactobacillus reuteri DSM 1738 es un probiótico ampliamente asociado con efectos positivos sobre algunas enfermedades gastrointestinales. Los estudios señalan la relación entre el CI y la composición del microbioma intestinal, ya que el TGI de los individuos menos frecuentemente colonizados por Lactobacillus está más enriquecido con coliformes formadores de gases. Desde esta perspectiva, la administración de L. reuteri tiene un efecto significativo en el tratamiento del cólico infantil, favoreciendo una reducción del tiempo diario de llanto y agitación. Objetivo: Investigar los efectos de la administración de Lactobacillus reuteri DSM 1738 en lactantes con cólicos. Metodología: Se trata de una revisión bibliográfica integradora que analiza artículos científicos en las bases PubMed, LILACS, SciELO y Scopus. Conclusiones: Ante ello, se puede concluir que la utilización de Lactobacillus reuteri DSM 1738 es favorable para reducir los cólicos infantiles en lactantes. 

Palabras clave: Lactobacillus reuteri DSM; Recién nacido.

Descargas

Los datos de descargas todavía no están disponibles.

Biografía del autor/a

Ester Cristina Stabili Brasileiro, Universidade Federal da Paraíba - UFPB

Ester Cristina Stabili Brasileiro - Universidade Federal da Paraíba - Graduanda em Enfermagem pela Universidade Federal da Paraíba - UFPB.
E-mail: esterstabili@gmail.com
ORCID:0009-0002-9267-3693

Amanda Meireles Medeiros , Universidade Federal da Paraíba - UFPB

Amanda Meireles Medeiros - Universidade Federal da Paraíba - Graduanda em Enfermagem pela Universidade Federal da Paraíba - UFPB

E-mail: mmeirelesamanda@gmail.com

ORCID: https://orcid.org/0009-0004-1077-1391 

Gabriela Saraiva Daltro Arnaud, Universidade Federal da Paraíba - UFPB

Graduanda em Enfermagem pela Universidade Federal da Paraíba, UFPB.

E-mail: gabrieladaltroo@gmail.com   

ORCID: https://orcid.org/0009-0005-9418-7420

 

Karen Roberta Ferreira Virgínio , Universidade Federal da Paraíba - UFPB

Graduanda em Enfermagem pela Universidade Federal da Paraíba - UFPB

E-mail: karenvirg123@gmail.com

ORCID: 0009-0004-7353-0560

 

Allana Petrúcia Medeiros de Miranda , Universidade Federal da Paraíba - UFPB

Especialista em Saúde da Criança pela Escola de Saúde Pública da Paraíba. Mestranda do Programa de Pós Graduação em Enfermagem da Universidade Federal da Paraíba - UFPB. 

E-mail: allanamiranda0608@gmail.com

ORCID: https://orcid.org/0000-0002-8228-3192

Fábia Barbosa de Andrade , Universidade Federal da Paraíba - UFPB

Docente da graduação de Enfermagem da Universidade Federal da Paraíba, UFPB. Doutora em Ciências da Saúde pela Universidade Federal do Rio Grande do Norte. - UFRN.

E-mail: fabiabarbosabr@gmail.com
ORCID: https://orcid.org/0000-0002-7055-8726

Citas

1. Ahmadipour S, Rahimi M, Khalili M. Probiotics for infantile colic. Heliyon. 2020 Mar [cited 2025 Aug 15];6(3):e03533. https://doi.org/10.1016/j.yclnex.2020.04.001

2. Firooz M, Eidy F, Abbasi Z, Hosseini SJ. Parental factors affecting the incidence of infantile colic: a systematic review. J Pediatr Rev. 2021 Apr [cited 2025 Aug 15];9(2):105-114. https://doi.org/10.32598/jpr.9.2.930.1

3. Farias TGS, Stamford TCM, Ribeiro VMS, Ladislau HFL, Medeiros JAC, Arnaud TMS et al. Synbiotic Foods: Use of Co-Encapsulation as a Way of Delivering Probiotics and Prebiotics. Avanços em Ciência e Tecnologia de Alimentos. 2021 [cited 2025 aug 20]. Available from: https://downloads.editoracientifica.com.br/articles/210303529.pdf

4. Saviano A, Brigida M, Migneco A, Gunawardena G, Zanza C, Candelli M, et al. Lactobacillus reuteri DSM 17938 (Limosilactobacillus reuteri) in diarrhea and constipation: two sides of the same coin?. Medicina. 2021 Jun [cited 2025 Aug 15];57(7):643. Available from: https://www.mdpi.com/1648-9144/57/7/643

5. Peng Y, Ma Y, Luo Z, Jiang Y, Xu Z, Yu R. Lactobacillus reuteri in digestive system diseases: focus on clinical trials and mechanisms. Front Cell Infect Microbiol. 2023 Aug [cited 2025 Aug 15];13:1254198. Available from: https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1254198/full

6. Indrio F, Enninger A, Aldekhail W, Al-Ghanem G, Al-Hussaini A, Al-Hussaini B et al. Management of the most common functional gastrointestinal disorders in infancy: the Middle East expert consensus. Pediatr Gastroenterol Hepatol Nutr. 2021 Oct [cited 2025 Aug 18];24(4):325‑336. https://pghn.org/DOIx.php?id=10.5223/pghn.2021.24.4.325

7. Souza MT, Silva MD, Carvalho R. Integrative review: what is it? How to do it? Einstein (Sao Paulo). 2010 [cited 2025 aug 20];8(1):102-6. Available from: https://pubmed.ncbi.nlm.nih.gov/26761761/

8. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systeatic reviews. BMJ. 2021 [cited 2025 aug 22];372(71). https://doi.org/10.1136/bmj.n71

9. Marzet CB, Burgos F, Del Compare M, Gerold I, Tabacco O, Vinderola G. Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG. Arch Argent Pediatr. 2022 Jan [cited 2025 Aug 16];120(1):e1‑e7. https://doi.org/10.5546/aap.2022.eng.e1

10. Zermiani APDRB, Soares ALPPP, de Moura BLSG, Miguel ERA, Lopes LDG, Santana NCS et al. Evidence of Lactobacillus reuteri to reduce colic in breastfed babies: Systematic review and meta-analysis. Complementary therapies in medicine, 2021 [cited 2025 aug 16];63, 102781. https://doi.org/10.1016/j.ctim.2021.102781

11. Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK. Probiotics to prevent infantile colic. Cochrane Database Syst Rev. 2019 Mar [cited 2025 Aug 19];3(3):CD012473. https://doi.org/10.1002/14651858.CD012473.pub2

12. Wadhwa A, Kesavelu D, Kumar K, Chatterjee P, Jog P, Gopalan S et al. Role of Lactobacillus reuteri DSM 17938 on crying time reduction in infantile colic and its impact on maternal depression: a real‑life clinic‑based study. Clin Pract. 2022 Jan 7 [cited 2025 Aug 18];12(1):37‑45. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788292/

13. Chau K, Lau E, Greenberg S, Jacobson S, Yazdani-Brojeni P, Verma N et al. Probiotics for infantile colic: a randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938. J Pediatr. 2015 Jan [cited 2025 Aug 21];166(1):74‑78. https://doi.org/10.1016/j.jpeds.2014.09.020

14. Dryl R, Szajewska H. Probiotics for management of infantile colic: a systematic review of randomized controlled trials. Arch Med Sci. 2018 Aug [cited 2025 Aug 21];14(5):1137–1143. https://doi.org/10.5114/aoms.2017.66055

15. Xu M, Wang J, Wang N, Sun F, Wang L, Liu XH. The Efficacy and Safety of the Probiotic Bacterium Lactobacillus reuteri DSM 17938 for Infantile Colic: A Meta-Analysis of Randomized Controlled Trials. PLoS One. 2015 Oct [cited 2025 Aug] 28;10(10):e0141445. https://doi.org/10.1371/journal.pone.0141445

16. Sung V, Hiscock H, Tang MLK, Mensah FK, Nation ML, Satzke C et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ. 2024 abr [cited 2025 aug 20];v348. Available from: https://www.bmj.com/content/348/bmj.g2107

17. Radesky JS, Zuckerman B, Silverstein M, Rivara FP, Barr M, Taylor JA et al. Inconsolable infant crying and maternal postpartum depressive symptoms. Pediatrics. 2013 Jun [cited 2025 Aug 16];131(6):e1857-e1864. Available from: https://publications.aap.org/pediatrics/article-abstract/131/6/e1857/31103/Inconsolable-Infant-Crying-and-Maternal-Postpartum?redirectedFrom=fulltext

18. Savino F, Galliano I, Savino A, Daprà V, Montanari P, Calvi C et al. Lactobacillus reuteri DSM 17938 probiotics may increase CC‑chemokine receptor 7 expression in infants treated with for colic. Front Pediatr. 2019 Aug [cited 2025 Aug 19];7:292. https://doi.org/10.3389/fped.2019.00292

19. Savino F, Garro M, Montanari P, Galliano I, Bergallo M. Crying time and RORγ/FOXP3 expression in Lactobacillus reuteri DSM17938-treated infants with colic: a randomized trial. J Pediatr. 2018 Jan [cited 2025 Aug 21];192:171–177.e1. https://doi.org/10.1016/j.jpeds.2017.08.062

20. Nation ML, Dunne EM, Joseph SJ, Mensah FK, Sung V, Satzke C et al. Impact of Lactobacillus reuteri colonization on gut microbiota, inflammation, and crying time in infant colic. Sci Rep. 2017 Nov 8 [cited 2025 Aug 22];7:15047. https://doi.org/10.1038/s41598-017-15404-7

21. Fatheree NY, Liu Y, Taylor CM, Hoang TK, Cai C, Rahbar MH et al. Lactobacillus reuteri for colicky infants: a randomized, double-blind, placebo-controlled clinical trial. The Journal of Pediatrics. 2017 Dec [cited 2025 aug 22];191:170-178.https://dx.doi.org/10.1016/j.jpeds.2017.07.036

22. Tantawy AAG, Sallam TH, Ibrahim DM, Sallam MT, Ragab IA. Pathogenesis and prognosis of neutropenia in infants and children admitted in a university children hospital in Egypt. Pediatr Hematol Oncol. 2013 Feb [cited 2025 Aug 16];30(1):51-59. Available from: https://pubmed.ncbi.nlm.nih.gov/23190007/

23. Gutiérrez-Castrellón P, Indrio F, Bolio-Galvis A, Jiménez-Gutiérrez C, Jiménez-Escobar I, López-Velázquez G. Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: systematic review with network meta-analysis. Medicine (Baltimore). 2017 Dec [cited 2025 Aug 21];96(51):e9375. https://doi.org/10.1097/MD.0000000000009375

Publicado

22-12-2025

Cómo citar

SILVA, Giovanna Stelling Brito de Araujo; BRASILEIRO, Ester Cristina Stabili; MEDEIROS , Amanda Meireles; ARNAUD, Gabriela Saraiva Daltro; VIRGÍNIO , Karen Roberta Ferreira; MIRANDA , Allana Petrúcia Medeiros de; ANDRADE , Fábia Barbosa de. The effects of Lactobacillus Reuteri DSM 1738 in infants with colic: an integrative review. Revista Ciência Plural, [S. l.], v. 11, n. 3, p. 1–15, 2025. DOI: 10.21680/2446-7286.2025v11n3ID41276. Disponível em: https://www.periodicos.ufrn.br/rcp/article/view/41276. Acesso em: 23 dic. 2025.

Número

Sección

Revisão Integrativa