Efectos de la administración de Lactobacillus reuteri DSM 1738 en lactantes con cólicos: una revisión integradora
DOI:
https://doi.org/10.21680/2446-7286.2025v11n3ID41276Abstract
Introduction: Infantile colic (IC) is a common condition affecting between 10% and 30% of infants worldwide. It is characterized by crying, a flushed face, flexed legs, and flatulence. Research has long connected Lactobacillus reuteri DSM 1738 to positive outcomes on certain gastrointestinal disorders, and a growing body of research also suggests a strong correlation between IC and the composition of the gut microbiome, as the intestinal flora of infants with colic frequently shows a lower presence of Lactobacillus and a higher count of gas-producing coliforms. In this context, administering L. reuteri has proven to have a notable impact on managing infantile colic, effectively reducing both the duration of daily crying and overall fussiness. Objective: This study aims to systematically investigate the therapeutic effects of administering Lactobacillus reuteri DSM 1738 in infants with colic. Methodology: An integrative literature review was employed and a comprehensive search was conducted across several key academic databases, including PubMed, LILACS, SciELO, and Scopus, to identify all relevant scientific literature. Results: Our initial search yielded 77 articles, from which 13 international studies were ultimately included following a rigorous selection process. The evidence synthesized from these studies consistently demonstrates that the use of Lactobacillus reuteri DSM 1738 in infants with colic leads to significant clinical improvement. Most notably, a reduction in crying by up to 50% was observed. Moreover, this intervention is also described as an effective strategy for managing gastrointestinal disturbances in infants. Conclusions: As a result, the findings from this review strongly support the use of Lactobacillus reuteri DSM 1738 as a beneficial and effective therapeutic approach for alleviating the symptoms of infantile colic in infants.
Keywords: Lactobacillus reuteri DSM; Newborn.
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1. Ahmadipour S, Rahimi M, Khalili M. Probiotics for infantile colic. Heliyon. 2020 Mar [cited 2025 Aug 15];6(3):e03533. https://doi.org/10.1016/j.yclnex.2020.04.001
2. Firooz M, Eidy F, Abbasi Z, Hosseini SJ. Parental factors affecting the incidence of infantile colic: a systematic review. J Pediatr Rev. 2021 Apr [cited 2025 Aug 15];9(2):105-114. https://doi.org/10.32598/jpr.9.2.930.1
3. Farias TGS, Stamford TCM, Ribeiro VMS, Ladislau HFL, Medeiros JAC, Arnaud TMS et al. Synbiotic Foods: Use of Co-Encapsulation as a Way of Delivering Probiotics and Prebiotics. Avanços em Ciência e Tecnologia de Alimentos. 2021 [cited 2025 aug 20]. Available from: https://downloads.editoracientifica.com.br/articles/210303529.pdf
4. Saviano A, Brigida M, Migneco A, Gunawardena G, Zanza C, Candelli M, et al. Lactobacillus reuteri DSM 17938 (Limosilactobacillus reuteri) in diarrhea and constipation: two sides of the same coin?. Medicina. 2021 Jun [cited 2025 Aug 15];57(7):643. Available from: https://www.mdpi.com/1648-9144/57/7/643
5. Peng Y, Ma Y, Luo Z, Jiang Y, Xu Z, Yu R. Lactobacillus reuteri in digestive system diseases: focus on clinical trials and mechanisms. Front Cell Infect Microbiol. 2023 Aug [cited 2025 Aug 15];13:1254198. Available from: https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1254198/full
6. Indrio F, Enninger A, Aldekhail W, Al-Ghanem G, Al-Hussaini A, Al-Hussaini B et al. Management of the most common functional gastrointestinal disorders in infancy: the Middle East expert consensus. Pediatr Gastroenterol Hepatol Nutr. 2021 Oct [cited 2025 Aug 18];24(4):325‑336. https://pghn.org/DOIx.php?id=10.5223/pghn.2021.24.4.325
7. Souza MT, Silva MD, Carvalho R. Integrative review: what is it? How to do it? Einstein (Sao Paulo). 2010 [cited 2025 aug 20];8(1):102-6. Available from: https://pubmed.ncbi.nlm.nih.gov/26761761/
8. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systeatic reviews. BMJ. 2021 [cited 2025 aug 22];372(71). https://doi.org/10.1136/bmj.n71
9. Marzet CB, Burgos F, Del Compare M, Gerold I, Tabacco O, Vinderola G. Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG. Arch Argent Pediatr. 2022 Jan [cited 2025 Aug 16];120(1):e1‑e7. https://doi.org/10.5546/aap.2022.eng.e1
10. Zermiani APDRB, Soares ALPPP, de Moura BLSG, Miguel ERA, Lopes LDG, Santana NCS et al. Evidence of Lactobacillus reuteri to reduce colic in breastfed babies: Systematic review and meta-analysis. Complementary therapies in medicine, 2021 [cited 2025 aug 16];63, 102781. https://doi.org/10.1016/j.ctim.2021.102781
11. Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK. Probiotics to prevent infantile colic. Cochrane Database Syst Rev. 2019 Mar [cited 2025 Aug 19];3(3):CD012473. https://doi.org/10.1002/14651858.CD012473.pub2
12. Wadhwa A, Kesavelu D, Kumar K, Chatterjee P, Jog P, Gopalan S et al. Role of Lactobacillus reuteri DSM 17938 on crying time reduction in infantile colic and its impact on maternal depression: a real‑life clinic‑based study. Clin Pract. 2022 Jan 7 [cited 2025 Aug 18];12(1):37‑45. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788292/
13. Chau K, Lau E, Greenberg S, Jacobson S, Yazdani-Brojeni P, Verma N et al. Probiotics for infantile colic: a randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938. J Pediatr. 2015 Jan [cited 2025 Aug 21];166(1):74‑78. https://doi.org/10.1016/j.jpeds.2014.09.020
14. Dryl R, Szajewska H. Probiotics for management of infantile colic: a systematic review of randomized controlled trials. Arch Med Sci. 2018 Aug [cited 2025 Aug 21];14(5):1137–1143. https://doi.org/10.5114/aoms.2017.66055
15. Xu M, Wang J, Wang N, Sun F, Wang L, Liu XH. The Efficacy and Safety of the Probiotic Bacterium Lactobacillus reuteri DSM 17938 for Infantile Colic: A Meta-Analysis of Randomized Controlled Trials. PLoS One. 2015 Oct [cited 2025 Aug] 28;10(10):e0141445. https://doi.org/10.1371/journal.pone.0141445
16. Sung V, Hiscock H, Tang MLK, Mensah FK, Nation ML, Satzke C et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ. 2024 abr [cited 2025 aug 20];v348. Available from: https://www.bmj.com/content/348/bmj.g2107
17. Radesky JS, Zuckerman B, Silverstein M, Rivara FP, Barr M, Taylor JA et al. Inconsolable infant crying and maternal postpartum depressive symptoms. Pediatrics. 2013 Jun [cited 2025 Aug 16];131(6):e1857-e1864. Available from: https://publications.aap.org/pediatrics/article-abstract/131/6/e1857/31103/Inconsolable-Infant-Crying-and-Maternal-Postpartum?redirectedFrom=fulltext
18. Savino F, Galliano I, Savino A, Daprà V, Montanari P, Calvi C et al. Lactobacillus reuteri DSM 17938 probiotics may increase CC‑chemokine receptor 7 expression in infants treated with for colic. Front Pediatr. 2019 Aug [cited 2025 Aug 19];7:292. https://doi.org/10.3389/fped.2019.00292
19. Savino F, Garro M, Montanari P, Galliano I, Bergallo M. Crying time and RORγ/FOXP3 expression in Lactobacillus reuteri DSM17938-treated infants with colic: a randomized trial. J Pediatr. 2018 Jan [cited 2025 Aug 21];192:171–177.e1. https://doi.org/10.1016/j.jpeds.2017.08.062
20. Nation ML, Dunne EM, Joseph SJ, Mensah FK, Sung V, Satzke C et al. Impact of Lactobacillus reuteri colonization on gut microbiota, inflammation, and crying time in infant colic. Sci Rep. 2017 Nov 8 [cited 2025 Aug 22];7:15047. https://doi.org/10.1038/s41598-017-15404-7
21. Fatheree NY, Liu Y, Taylor CM, Hoang TK, Cai C, Rahbar MH et al. Lactobacillus reuteri for colicky infants: a randomized, double-blind, placebo-controlled clinical trial. The Journal of Pediatrics. 2017 Dec [cited 2025 aug 22];191:170-178.https://dx.doi.org/10.1016/j.jpeds.2017.07.036
22. Tantawy AAG, Sallam TH, Ibrahim DM, Sallam MT, Ragab IA. Pathogenesis and prognosis of neutropenia in infants and children admitted in a university children hospital in Egypt. Pediatr Hematol Oncol. 2013 Feb [cited 2025 Aug 16];30(1):51-59. Available from: https://pubmed.ncbi.nlm.nih.gov/23190007/
23. Gutiérrez-Castrellón P, Indrio F, Bolio-Galvis A, Jiménez-Gutiérrez C, Jiménez-Escobar I, López-Velázquez G. Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: systematic review with network meta-analysis. Medicine (Baltimore). 2017 Dec [cited 2025 Aug 21];96(51):e9375. https://doi.org/10.1097/MD.0000000000009375
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