Effect of simvastatin on coagulation in rats with abdominal sepsis

Authors

  • Aldo Cunha Medeiros UFRN, Brazil
  • Irami Araújo-Filho UFRN, Brazil
  • Camila Carlos Tavares UFRN, Brazil
  • Nathalia Louise R Alves Mota UFRN, Brazil
  • Amália Cinthia Meneses Rêgo
  • Ítalo Medeiros de Azevedo
  • Vanessa de Fátima Lima Paiva Medeiros

DOI:

https://doi.org/10.20398/jscr.v3i2.3569

Keywords:

Coagulation, Sepsis, Peritonitis, Simvastatin

Abstract

Objective: This study aimed to evaluate the Simvastatin pleiotropic effects in coagulation on rats with abdominal sepis. Methods: Twelve Wistar rats (three months, 273-297g) were randomly assigned to abdominal septic group (n=6), induced by cecal ligation and pucture (CLP) and septic group with a previous drug treatment (n=6). The Simvastatin/CLP group was treated with oral simvastatin (10 mg/Kg), eighteen and two hours before the CLP procedure or normal saline solution 0.9%. Peripheral blood laboratory determinations: Platelets, ativated troboplastin parcial time, activated coagulation time, protrombin time, trombin time, fibrinogen dosage, factor VII and factor VIII. Statistical analysis was done by ANOVA and Tukey test, with p<0.05. Results: It wasn’t found any significant statistic differences between the groups. Conclusion: Simvastatin did not change the coagulation in rats with abdominal sepsis, according to this experimental model.

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Published

03-06-2013

How to Cite

MEDEIROS, Aldo Cunha; ARAÚJO-FILHO, Irami; TAVARES, Camila Carlos; MOTA, Nathalia Louise R Alves; RÊGO, Amália Cinthia Meneses; AZEVEDO, Ítalo Medeiros de; MEDEIROS, Vanessa de Fátima Lima Paiva. Effect of simvastatin on coagulation in rats with abdominal sepsis. JOURNAL OF SURGICAL AND CLINICAL RESEARCH, [S. l.], v. 3, n. 2, p. 68–74, 2013. DOI: 10.20398/jscr.v3i2.3569. Disponível em: https://www.periodicos.ufrn.br/jscr/article/view/3569. Acesso em: 20 dec. 2025.

Issue

Vol. 3 No. 2 (2012)

Section

ORIGINAL ARTICLE

License

Uma vez aceito o artigo para publicação, os autores transferem os Direitos Autorais (copyright) para o J Surg Cl Res, responsabilizam-se pelo conteúdo do trabalho, confirmam sua originalidade e se comprometem a não publicá-lo em outros periódicos na íntegra ou em parte.